Mexicos squishy crunchy ancestral eats

first_imgFrozen gusanos de maguey, or agave worms, are shown at the San Juan market in Mexico City on July 8. Washington Post photo by Nick Miroff More live snails for sale at the San Juan market in Mexico City. Washington Post photo by Nick Miroff No related posts. MEXICO CITY — The San Juan market is Mexico City’s most famous deli of exotic meats, where an adventurous shopper can hunt down hard-to-find critters like ostrich, wild boar and crocodile. Only the city zoo offers greater species diversity.But the priciest items in the market aren’t the armadillo steaks or even the bluefin tuna.That would be the frozen chicatanas — giant winged ants — at around $225 a pound.Apparently, they’re delicious in salsa.“Much better than the junk food they sell in supermarkets,” said vendor Benjamín Rodríguez, showing off his ant stash beside trays of crispy fried crickets and live snails.“All natural,” he said with a wry grin.Rodríguez and the other bug mongers of San Juan offer their wares as “pre-Hispanic” foods, a nod to the Aztecs, Mixtecs and other civilizations that flourished for millennia here on diets rich in grubs, grasshoppers and other edible invertebrates.Insect-eating was long regarded with shame and disgust by elite Mexicans who viewed the practice as a vestige of rural backwardness. But bugs have crawled onto the menus of some of the country’s most celebrated eateries in recent years, as top chefs seek out esoteric regional ingredients for cuisine known as “alta mexicana” (high-end Mexican).center_img “These are foods that were eaten in pre-Hispanic times because there wasn’t meat, but now they’re seen as luxurious,” said Lesley Tellez, a food writer who leads tours of Mexico’s markets and kitchens.“It’s part of a larger trend of bringing traditional Mexican elements back to the table and giving them [the] value they deserve,” she said.Mexico has some 300 to 550 species of edible insects, more than any country in the world, according to the U.N. Food and Agriculture Organization (FAO), which issued a 200-page report this year in praise of entomophagy — insect-eating — as a promising source of sustainable protein.“The case needs to be made to consumers that eating insects is not only good for their health, it is good for the planet,” the FAO report read.The tiny comestibles are very high in protein, it noted, especially compared to meats like beef and pork.In the poor, rural communities of Mexico’s central highlands and southern states, families have been eating insects for generations as tradition, but also out of necessity.“We ate them because we were hungry,” said Mario Rendón, a bug supplier at the San Juan market. He said he grew up in the southern state of Guerrero learning to catch and consume them seasonally.When the rains came in late spring, he and his brothers would accompany their father on cricket-capturing expeditions, trapping them in nets. They also learned to pull meaty grubs — gusanos de maguey — from flowering agave plants.“Fry them up with a little salt and lime,” Rendón said. “Delicious.”Most of Mexico’s edible insects are caught wild, not farmed, then sold at regional markets or trucked into the cities.Among the most treasured delicacies are escamoles (ant larvae), cumiles (stink bugs) and ahuatle (water bug eggs), dubbed “Mexican caviar.”The stink bugs are typically eaten live and are prized for their powerful anise-like flavor and cinnamon finish. Put on a plate or inside a tortilla, they don’t exactly sit still.“Eating them in a taco can be a little weird,” said Mexico City restaurant manager Eduardo Lucero. “They sorta escape into your mouth when you bite down.”Lucero’s restaurant, Corazon de Maguey, offers a seasonal menu in the spring with seven types of insects and has organized mezcal-and-bug festivals to wash the critters down with doses of the strong, agave-derived liquor.“All the insects sell really well,” he said.But since supplies are irregular, and prices high, they remain mostly a delicacy item in Mexico City restaurants. One exception: the ubiquitous and widely affordable chapulines — grasshoppers or crickets — that are typically sautéed in salt and garlic and rolled in tacos or gobbled by the handful.“Kids love them,” said Ricardo Castañeda, a vendor at the San Juan market who sells three types of the insects: adults, juveniles and a version fried in garlic and olive oil.“They walk by my stall and tell their parents: ‘I want some!’”Castañeda offered a sample. It was crunchy and a bit hollow, almost like eating a bland wafer. With legs.Though crickets remain abundant in Mexico, other wild-caught insect species have grown more scarce with their growing popularity, and their escalating prices have further accelerated their decline.In Mexico’s Hidalgo state, cradle of the highly prized escamol (ant larvae), nests are routinely destroyed by collectors who leave the colonies exposed to the elements after harvesting the larvae, said escamol entrepreneur Armando Soria.Soria launched an experiment two years ago, attempting to farm the larvae by transplanting nests and providing abundant food sources for the ants. His harvests have been modest so far, but he says he plans to expand.“People have a reticence to eating insects,” he said. “It’s like a mental allergy.”“But they offer delicious flavors,” Soria insisted. “They’re a solution to so many problems. They don’t need tractors or irrigation. Just people willing to give them a try.”Washington Post special corespondent Gabriela Martínez contributed to this report.© 2013, The Washington Post Facebook Commentslast_img read more

Top Stories

first_img Top Stories “I thought he answered the bell well,” Cardinals coach Bruce Arians said. “There was a good throw, he was going to intercept the one, but it was a really high throw and he couldn’t get it. But I thought he had great coverage on a couple plays.”True, it’s not as if Bethel blanketed receivers to the point where completions were not happening on his side of the field. But he was not really beaten on any play, and when a catch was made in front of him, he tackled well.In a lot of ways, that’s all a cornerback can do.“Definitely felt good to be out there and go out there and try to make some plays,” Bethel said. “I was there for a lot of balls; I feel like there’s a couple of them I probably could have played a little better and knocked out, but definitely was glad to be able to get that chance.”For Bethel, it was important to show that he can be more than a special teams ace. Thus far into his career he has yet to prove capable of being a consistent cornerback, though this past week in practice has allowed him to go toe-to-toe with receivers like Larry Fitzgerald and John Brown. Saturday he matched up with an elite receiver in Maclin, and did not at all appear to be out of his league. The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo You would think it would help his confidence, but Bethel said he’s always believed he could handle the role.“For me, I kind of always felt like I had the physical abilities to go out there and play with everybody,” he said. “It’s been more, for me, working on technique and mentally knowing the game and knowing what I’m supposed to do. I’ve really been working on that and I’ve got a chance to go out there and kind of put it to the test today.“So definitely glad that I got that chance and I’m just going to keep working.”That means going back and watching the film, which now includes him facing off against some elite receiver talent.“You build off of it, see what you’ve got to fix and just fine-tune little things and just keep working to get better,” he said. – / 45 Comments   Share   Former Cardinals kicker Phil Dawson retires GLENDALE, Ariz. — Cornerback Justin Bethel spent all of this past week working with the first-team defense as Jerraud Powers has been sidelined with an oblique injury.With Powers sitting out Saturday’s preseason opener against the Kansas City Chiefs, Bethel was tabbed to start opposite Patrick Peterson. The fourth-year pro stepped up and played well, tallying three tackles — one of which was for a loss — along with one pass defensed in a game Arizona lost by a score of 34-19. In one early-game play, he also ran stride-for-stride with star Chiefs wideout Jeremy Maclin, getting his head turned around at the last second to help prevent a long completion without incurring a pass interference penalty. Derrick Hall satisfied with D-backs’ buying and selling Arizona Cardinals cornerback Justin Bethel (28) breaks up a pass intended for Kansas City Chiefs wide receiver Jeremy Maclin (19) during the first half of an NFL preseason football game, Saturday, Aug. 15, 2015, in Glendale, Ariz. (AP Photo/Matt York) Grace expects Greinke trade to have emotional impactlast_img read more

Splat A lucky strike and the telltale red splodge

first_imgSplat! A lucky strike and the telltale red splodge that your nightly tormentor has sucked its last blood vessel.Staring at the mess on the wall, you might find it hard to believe that so small an insect can carry so much blood. But female mosquitoes have a knack for eating, doubling their body weight with each meal.”They can barely fly,” laughs Leslie Vosshall, a neurobiologist at Rockefeller University, who’s hoping to control mosquitoes, as well as the diseases they carry, by switching off their enormous appetite.In a paper published Thursday in the journal Cell, Vosshall and her team demonstrate how human diet drugs satiate mosquitoes’ bloodlust for several days — so they are less likely to feed on humans and spread diseases and will also produce fewer offspring.”When they’re hungry, these mosquitoes are super motivated. They fly toward the scent of a human the same way that we might approach a chocolate cake,” Vosshall says. “But after they were given the drug, they lost interest.”The method taps into female mosquitoes’ natural gluttony. Each supersize meal provides enough nutrients to support the typical clutch of around 100 eggs. After she has eaten, the mosquito loses her appetite for at least four days while her eggs develop.But as soon as a mosquito lays her eggs in a pool of stagnant water, she is off again in search of a mate and a meal. A female mosquito can breed several times in her lifetime of six to eight weeks, and in the process she can bite many people — which makes her a reliable vessel for spreading diseases.Vosshall and her team set out to identify and manipulate the hormone pathways responsible for this behavior. Because similar pathways for hunger are found in many animals — that is, they have similar evolutionary roots — she started with off-the-shelf human diet drugs.”On a lark we thought, ‘Let’s go for it. Let’s do the craziest experiment possible and get some human diet drugs and see if they work on mosquitoes,’ ” Vosshall told NPR.”It was surprising that it worked so well.”In a series of lab experiments, Aedes aegypti mosquitoes (which spread dengue fever, yellow fever and Zika virus) were fed these diet drugs by mixing them into a chemical solution that also contained ATP — a molecule found inside most animal cells that mosquitoes find irresistible. The diet drugs came in powder form. For several days after drinking this solution, the mosquitoes showed little interest when offered the bare arms of human volunteers. Even the smell of dirty nylon stockings, saturated with human scent, was not enough to tempt them.After testing human diet drugs, the team homed in on the specific receptors that these drugs activate inside the mosquito brain. Then they could search through a general catalog of more than 265,000 chemicals to find a new suite of drugs that also activate this receptor — but that control only the appetite of mosquitoes and similar biting insects.”Human drugs are owned by pharmaceutical companies, and so we wanted to find something where the intellectual property wasn’t locked up. That’s important in [developing countries] for deployment,” Vosshall explains. And for obvious reasons, widely releasing human diet drugs into the environment is not a good idea.In recent years, scientists have developed an advanced arsenal of tools in the war against mosquitoes — from potent new insecticides to gene drives and bacterial infection. But rarely have they tried to control mosquitoes’ behavior.”There is a real need for novel approaches to controlling insects that transmit diseases,” says James Logan of the London School of Hygiene & Tropical Medicine, who was not involved in the study.According to the World Health Organization, mosquito-borne diseases — such as malaria, yellow fever, dengue and Zika virus — are responsible for millions of deaths each year.”Humans have been trying to fight mosquitoes ever since there were humans,” says Vosshall, pointing to an impressive variety of control methods — from rolled-up newspapers to genetic engineering.”All of these advances are complementary,” says Vosshall, who argues that no single innovation can eradicate mosquito-borne diseases and advocates using several methods at once. “Our behavior control is something else in this portfolio,” she says.This strategy seeks to reduce mosquito numbers rather than annihilate the insects entirely, which could have unintended ecological consequences. “I do worry about the balance of nature,” Vosshall says.But not everyone agrees that eradicating mosquitoes is a bad idea. “A recent study suggested that malaria mosquitoes do not play a vital role in the ecosystem, and therefore their removal would have minimal impact,” Logan says.”I don’t think we will ever eradicate all mosquitoes. But I do think that one day we will eradicate individual species,” he says.It’s early days for this novel approach to mosquito control, and it remains unclear how substantially it would stem the spread of disease in the real world. Meanwhile, more lab research must be done to develop these drugs so that they are potent and cheap enough to use in the field.”Transitioning from laboratory experiments to the field is always difficult,” Logan says. “One of the biggest challenges will be devising a system that attracts mosquitoes well enough and allows them to feed on this substance effectively.””You need to have dispensers; you need some way to attract female mosquitoes and have that work in local communities,” says Vosshall, looking to the logistical hurdles ahead.Putting billions of mosquitoes on an unwitting diet was never going to be easy.Thomas Lewton is a freelance science journalist and videographer who divides his time between London and Kampala, Uganda. You can follow him on Twitter: @thomaslewton. Copyright 2019 NPR. To see more, visit https://www.npr.org.last_img read more

Mark Zuckerberg Gives a Lesson in How Not to Lead in a

first_img Opinions expressed by Entrepreneur contributors are their own. Facebook 2019 Entrepreneur 360 List Next Article Guest Writer April 3, 2018 Image credit: NurPhoto | Getty Images Add to Queue Zuckerberg is renowned for inventing Facebook, but his reputation for leading it is in tatters. Samuel Edwards Mark Zuckerberg Gives a Lesson in How Not to Lead in a Crisis 5 min read Digital Marketing Strategist –shares Apply Now » The only list that measures privately-held company performance across multiple dimensions—not just revenue. For a while, Facebook could do no wrong. All you have to do is take a quick look at the Facebook stock chart and you’ll see a company that has watched its value rise nearly 500 percent over the past five years alone. But that same chart will also show you a hefty decline since the middle of March. In all honesty, CEO Mark Zuckerberg is to blame. Cambridge Analytica exposed Zuckerberg’s greatest flaw.It would be safe to say that public trust in Facebook is at an all-time low. If the past year has taught us anything, it’s that trust must be continually cultivated, no matter how much of it you think your organization has.Perhaps it was an inflated sense of public trust, an attitude of invincibility, or an unwillingness to own up to responsibility that led Zuckerberg, COO Sheryl Sandberg and other Facebook executives to take a painfully long time to formulate a response to the news that data firm Cambridge Analytica gained access to millions of its users’ data three years ago. However, at this point, does it really matter? The problem is that Facebook is developing a poor track record of managing crises.Now that people know just how much of their personal data Facebook has, the last thing the company can afford is for people to view the social network giant as being irresponsible. Unfortunately, Zuckerberg’s response in the wake of this crisis has done little to instill confidence and accountability.Zuckerberg and the company must decide whether they’re going to embrace the responsibility they have. They’ve walked into this mess by amassing mounds of personal information on users. If they don’t want to deal with the responsibility that comes with it, they need to step out of the way. That’s the blunt truth.To Zuckerberg’s credit, he finally spoke up. “I’ve been working to understand exactly what happened and how to make sure this doesn’t happen again,” Zuckerberg wrote in a post on his profile. “I promise you we’ll work through this and build a better service over the long term.”Zuckerberg’s response was, arguably, another poor PR move. He said no more than you’d expect but far later than he should have. Plus, it was sterile and vague. He left many wondering if Facebook is really doing enough to protect user data.Related: Read Mark Zuckerberg’s Full Statement on Facebook’s Data ScandalTakeaways from Facebook’s PR debacle.Taking your personal feelings and data out of the equation, the Facebook-Cambridge Analytica crisis has been a textbook PR case study in what not to do. As we look at it in more detail, here are a few of the takeaways and lessons business owners and entrepreneurs should spend some time studying.1. Don’t delay.The issue most people had with Facebook’s response was that it took so long for one to be formulated and publicized. Since the company obviously was aware of what was going on, it was unacceptable and disingenuous to keep people waiting for days.One of the first rules of good crisis management is to get ahead of the problem. The sooner you can address the issue, the better you can shape the public narrative and response.Related: Read the Controversial 2016 Facebook Memo in Which an Exec Argues for ‘Growth at Any Cost’2. Apologize.Zuckerberg’s eventual response was 936 words long. While it contained a bunch of corporate language and legal jargon, do you know what word was completely missing? The simple word sorry.It’s not always necessary to spend a bunch of time apologizing in the wake of a crisis, but you do need to say sorry — even if the incident was largely outside your control. It humanizes your brand and makes you look like you care.Related: Mark Zuckerberg Doesn’t Seem Very Sorry or Very Forgiven3. Act.The final lesson is to take action. If you say you’re going to do something, make sure your actions follow your speech. While it remains to be seen if Facebook will maintain a stiffer posture on responsibly stewarding user data, there has been some initial activity.Zuckerberg recently posted to his Facebook page that new privacy and security settings have been placed at the top of everyone’s Newsfeed so that users can easily disable apps they are no longer using and tweak their security settings to fit their preferences. If nothing else, it’s a start.Related: Facebook’s Data Scandal and Europe’s New Data Privacy Rule Have Massive Implications for U.S. EntrepreneursFor Zuckerberg and Facebook, the good news is there will be plenty of opportunities to rebuild trust with users. However, if they’re going to restore that trust, they must learn from their mistakes and make it a point to improve their crisis management efforts and address the PR shortcomings they’ve repeatedly been characterized by. As an outsider looking in, you can also learn from their mistakes and prepare your own business for handling crises with more grace.last_img read more

Richard Branson Says the 95 Workday Grind Is About to Die Heres

first_img Richard Branson Says the 9-5 Workday Grind Is About to Die. Here’s Why. –shares 2 min read Learn how to successfully navigate family business dynamics and build businesses that excel. Nina Zipkin Register Now » Image credit: Axelle/Bauer-Griffin | Getty Images December 19, 2018 Richard Branson believes the 5-day, 9-5 work week will eventually become extinct.In a recent blog post, the Virgin Group founder cited a familiar argument, that technological innovation — especially advances that do away with the need for people to operate everything from factory machinery to cars and planes — will change work as we know it.But he writes that this doesn’t necessarily have to be something to fear. Instead it can be an opportunity to shake things up for the better, and to accelerate the creation of smarter working practices for everyone.Related: Advice for Elon Musk From Richard Branson, Arianna Huffington and Mark Cuban“One useful idea is for governments to provide tuition for workers to gain the technical skills needed in the new marketplace, in exchange for public service. We need more creative solutions too,” Branson explains.Two other ideas that Branson supports are the proliferation of three and four day weekends and job sharing. These would prioritize a work infrastructure that allows employees to have full lives outside of an office, to spend time with friends and family, to  devote time to the things they are passionate about, and to focus on being physically and mentally healthy.Branson explained how flexible work is a big part of how he leads Virgin Group. “If you trust people and treat them as adults, they will repay you by working effectively and efficiently,” he wrote. “Choice can empower people to make good decisions and feel positive about their workplace, helping to keep great employees and attract new talent. If we all work smarter, we won’t have to work longer.”center_img Work-Life Balance Add to Queue The Virgin Group founder urges businesses to implement flexible work practices to get the most from their employees. Staff Writer. Covers leadership, media, technology and culture. Free Webinar | July 31: Secrets to Running a Successful Family Business Next Article Entrepreneur Stafflast_img read more

Bidalgo Launches Industry First AssetLevel Data for Google App Campaigns to Give

first_imgBidalgo Launches Industry First Asset-Level Data for Google App Campaigns to Give App Marketers Greater Accuracy and Control MTS Staff WriterApril 26, 2019, 7:32 pmApril 26, 2019 With Post-Attribution, Asset-Level Heuristic Data, Bidalgo Automation Brings a 30% Lift in ROASBidalgo, a leading provider of ad automation software and services for app marketers, announced the launch of Asset Heuristic Data (Asset HD) for Google App Campaigns, providing app marketers with post-attribution, asset-level data and enhanced AI-powered automation for install campaigns on Google properties. Now, for the first time since Google transitioned all app install campaigns to Google App Campaigns (previously “Google UAC”) in October of 2017, app marketers have access to accurate reporting data down to the asset level, so that they can analyze creative performance and optimize campaigns accordingly. In early tests, marketing partners using Bidalgo’s Automation for Google App Campaigns have increased their Return On Ad Spend (ROAS) 30 percent.Google App Campaigns run optimized install campaigns on inventory across all relevant Google properties, including Google Play, Search, YouTube and the Google Display Network. Currently, Measurement Partners don’t have transparency to asset-level data, leading to a lack of accurate, post-attribution data throughout the industry. Google provides marketers with approximated reporting on basic, pre-attribution data such as impressions, clicks and conversions, but the numbers are often difficult to interpret and take action on. Bidalgo’s algorithm for Asset HD relies on user funnel, pre-attribution data and other inputs to provide highly accurate information about the post-install performance of each asset as it affects revenue, payers, transactions and more.Marketing Technology News: Data Privacy: Balancing Personalization and Security in the Age of Transparency“Google App Campaigns are an incredibly powerful yet simple way for app marketers to drive high-quality installs,” said Niv Yemini, CTO & co-founder of Bidalgo. “But at the same time, it has taken away some of the control from app marketers who are used to having more dials and levers they can adjust in order to optimize their campaigns. With our solutions for Google App Campaigns, we are putting the power back into those marketers’ hands by providing greater transparency into asset performance and enabling them to better manage and optimize their campaigns.”Marketing Technology News: MGH Survey Finds Nearly Half of US Diners Have Tried a New Restaurant Because of its Social Media PostsBidalgo improves Google App Campaigns by providing:Asset HD – While Google only provides pre-attribution, campaign-level data for metrics such as impressions, clicks and installs, Bidalgo provides Asset Heuristic Data (Asset HD). Bidalgo uses a data science-driven heuristic technique to calculate asset-level performance, including Return On Ad Spend (ROAS), based on post-install attribution data from leading mobile measurement partners. This enables the breakdown of performance for assets including text, video, display image and HTML5 playable units. Until now, these assets were only looked at collectively.AI-Powered Automation – Bidalgo’s proprietary AI algorithms create a campaign using smart asset selection by looking at the assets’ historical data. Once the best assets have been determined, it analyzes their performance and adds or removes as needed. Marketers can now build campaigns based on the best performing assets and optimize campaigns automatically using that data.Marketing Technology News: Grant Thornton’s Tax practice embraces Microsoft Power BI AI-powered automationapp marketersAsset Heuristic DataBidalgoGoogle App CampaignsMarketing TechnologyNews Previous ArticleBlueshift Appoints LendingTree’s Former VP of Marketing, Josh Francia, as Chief Growth OfficerNext ArticleSalesLoft Scoops $70 Million Series D to Fuel Growth in Sales Technologylast_img read more

Researchers reveal how some cancers trick healthy cells into protecting tumors

first_img Source:https://www.chla.org/ Reviewed by James Ives, M.Psych. (Editor)Nov 30 2018Many factors affect cancer treatment outcome, such as the size and location of the tumor, availability of effective treatments, and timing of intervention. But some cancers are so aggressive that outcome is poor, even after early diagnosis and chemotherapy. Researchers have focused their attention on trying to understand what makes some cancers less treatable than others. Now, researchers at Children’s Hospital Los Angeles reveal a mechanism by which some cancers trick healthy cells into protecting tumors.Yves DeClerck, MD, of the Children’s Center for Cancer and Blood Diseases and the Saban Research Institute at Children’s Hospital Los Angeles, has dedicated his career to understanding how cancer cells interact with the surrounding normal tissue to escape the effects of therapy. Research has shown that tumors with high levels of a protein called Plasminogen Activator Inhibitor 1 (PAI-1) are more aggressive and are associated with poorer outcomes. In the new study, published November 20th in the journal Cell Reports, DeClerck’s team demonstrated that cancer cells use PAI-1 to trick the body’s immune system into supporting the cancer.DeClerck and his team, led by postdoctoral research fellow Marta Kubala, PhD, characterized a relationship between tumors and the immune system. “In this study, we focused on the role of immune cells called macrophages and how PAI-1 affects their activity,” explains Kubala. As important players in the immune system, macrophages find and destroy cancer cells or foreign invaders like bacteria. While macrophages are normally considered anti-cancer, DeClerck’s team showed that PAI-1 pushes macrophages into an alternate, pro-cancer state (called M2) by recruiting common players in the immune system – IL-6 and STAT3 – effectively signaling to the macrophages to support rather than attack tumor cells.”A macrophage can either be a friend or an enemy to cancer cells,” explains DeClerck, who is also a professor of pediatrics at the Keck School of Medicine of the University of Southern California. “The cancer communicates with the macrophages, telling them to become friendly. So, the macrophages change their behavior and support the tumor.” In altering the function of surrounding, healthy tissue, the cancer is better able to survive and spread.Related StoriesSugary drinks linked to cancer finds studyMother calls for protein shake regulation after daughter diesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe team around DeClerck also shows that cancer cells can use PAI-1 to promote movement of these pro-cancer M2 macrophages into the tumors, where they protect the cancer and repair any damage that chemotherapy may have inflicted. This symbolic one-two punch culminates in a stronger, more difficult-to-treat cancer.DeClerck and his team have uncovered what appears to be a very common mechanism used by many cancers to commandeer part of the body’s immune system. In order to investigate how broadly this cellular communication could impact cancer treatment, DeClerck’s team studied the National Institute of Health’s Cancer Genome Atlas, a library of genetic information from more than 11,000 patient samples, and found that many different cancers have this relationship. “We looked at patient data from neuroblastoma and breast, prostate, colon, and lung cancers. Every time we see higher levels of PAI-1, we see more evidence of pro-cancer M2 macrophages,” says DeClerck.This new understanding of just how PAI-1 communicates with macrophages to change their activity has the potential to alter our approach to cancer treatment since these findings are applicable to most types of cancer. “It is clear that the tumor microenvironment, including cells of the immune system, is crucial in cancer development,” explains Kubala.While cancers vary widely in terms of location, treatment, and survival rates, their manipulation of macrophages represents a common thread, which is important for devising improved treatments for aggressive cancers. “Targeting PAI-1 could be beneficial in cancer,” DeClerck says, “but much more work needs to be done.” He cautions that the answer is not as simple as eliminating PAI-1, which is also made in healthy tissue and is an important part of the blood clotting process. But these results, which uncover a complete pathway of communication between tumors and macrophages, lay the foundation for a promising avenue of research.​​last_img read more

Google Microsoft and Starbucks are some of the best places to work

first_img Facebook, Starbucks, Ernst & Young are among top U.S. companies for professional development Let’s face it, some jobs are just better than others. The best companies to work for are headed by effective leaders. They offer competitive salaries, opportunities for advancement, payroll bonuses, health insurance and other useful perks that enhance your quality of life outside the office.Which U.S. companies offer all that and more?The compensation, culture and career monitoring website Comparably.com ranked them by region using data collected from 10 million employee ratings and thousands of salary records.Highspot, a sales software platform, took the top spot in Seattle and Google beat out all the Silicon Valley and San Francisco companies. Hubspot, a software marketing service, was the best in the Boston area, according to workers.The software company Workfront leads the pack in the Salt Lake City area. The business process outsourcing firm TaskUs is the top company in the Los Angeles region. UiPath, an automation vendor, is the best company to work for in the New York area.Comparably asked workers questions in 20 culture categories including work-life balance, compensation, professional development and leadership.”What stands out is that these are the best companies across all those categories,” said Comparably’s CEO and founder Jason Nazar. The list is “breaking down how a company is performing to its workers, how happy people are with their pay, and what they think about their team members and managers.”Comparably organized the winners by region since most companies are vying for the best talent on a local level, according to Nazar. The list is also useful for workers who are seeking employment within a specific market “regardless of company size,” Nazar said.The winners range from startups with a few employees to Fortune 50 businesses with more than 500 staff members.”Employees are expecting the best of both worlds,” Nazar said. “They want earlier stage companies to offer the same benefits that they’d get at large-scale companies. At large companies, they want the flexibility and ownership that they’d get in smaller companies.” Explore further Best places to work in Seattle regionHighest ranked 1. Highspot (Seattle) 2. Edifecs (Bellevue, Washington) 3. T-Mobile (Bellevue, Washington) 4. Microsoft (Redmond, Washington) 5. Costco (Issaquah, Washington) 6. Akvelon (Bellevue, Washington) 7. Starbucks (Seattle) 8. Hiya (Seattle) 9. Karat (Seattle) 10. RealSelf (Seattle) 11. Shyft Technologies (Seattle) 12. Amazon (Seattle) 13. Zipwhip (Seattle) 14. Porch.com (Seattle) 15. Liquid Planner (Seattle)Best places to work in Los AngelesHighest ranked 1. TaskUs (Santa Monica, California) 2. PeerStreet(Los Angeles) 3. Acorns (Irvine, California) 4. Barry’s Bootcamp (Los Angeles) 5. Golden Hippo (Woodland Hills, California) 6. InvestCloud (West Hollywood, California) 7. Blizzard Entertainment (Irvine, California) 8. Chrome River Technologies (Los Angeles) 9. Signal Sciences (Los Angeles) 10. SmartBug Media (Newport Beach, California) 11. FaceFirst (Los Angeles) 12. Seek Capital (Los Angeles) 13. Tinder (Los Angeles) 14. CornerStone On Demand (Santa Monica, California) 15. BQE Software (Torrance, California)Best places to work in Boston regionHighest ranked 1. HubSpot (Cambridge, Massachusetts) 2. Drift (Boston) 3. LogMeIn (Boston) 4. Drizly (Boston) 5. Dynatrace (Waltham, Massachusetts) 6. Celtra (Boston) 7. Notarize (Boston) 8. Jabra (Boston) 9. Acquia (Boston) 10. Buildium (Boston) 11. ConnectRN (Waltham, Massachusetts) 12. Pegasystems (Cambridge, Massachusetts) 13. ClearGov (Maynard, Massachusetts) 14. Liberty Mutual Insurance (Boston) 15. TaxJar (Woburn, Massachusetts)Best places to work in San Francisco/Silicon ValleyHighest ranked 1. Google (Mountain View, California) 2. Sitetracker (Palo Alto, California) 3. Salesforce (San Francisco) 4. Upgrade (San Francisco) 5. Nevro (Redwood City, California) 6. Sunrun (San Francisco) 7. Periscope Data (San Francisco) 8. Infrrd (San Jose, California) 9. Globant (San Francisco) 10. Intuit (Mountain View, California) 11. Sonder (San Francisco) 12. LinkedIn (Sunnyvale, California) 13. TripActions (Palo Alto, California) 14. Mixpanel (San Francisco) 15. Asana (San Francisco)Best places to work in New York regionHighest ranked 1. UiPath (New York) 2. CultureIQ (New York) 3. Greenhouse Software (New York) 4. Overtime (Brooklyn) 5. WhiteSource (New York) 6. International Flavors & Fragrances (New York) 7. ADP (Roseland, New Jersey) 8. Gartner (Stamford, Connecticut) 9. Wibbitz (New York) 10. Pipedrive (New York) 11. Next Caller (New York) 12. AdTheorent (New York) 13. Accenture (New York) 14. Mobilewalla (New York) 15. Rokt (New York)Best places to work in Salt Lake City regionHighest ranked 1. Workfront (Lehi, Utah) 2. Qualtrics (Provo, Utah) 3. Overstock.com (Midvale, Utah) 4. Divvy (Lehi, Utah) 5. Vivint Smart Home (Provo, Utah) 6. Disruptive Advertising, Inc. (Lindon, Utah) 7. BambooHR (Lindon, Utah) 8. Canopy Tax (Lehi, Utah) 9. Skipio(Lehi, Utah) 10. TravelPass Group (Lehi, Utah) 11. Lingotek (Lehi, Utah) 12. Simplus (Salt Lake City) 13. Boostability (Lehi, Utah) 14. Finicity (Murray, Utah) 15. Lift Credit (Provo, Utah)MethodologyComparably’s Best Companies list is derived from sentiment ratings provided by employees in each region who anonymously rated their employers on Comparably.com between March 8, 2018, and March 8, 2019. To qualify, large companies must have a minimum of 50 employee participants and small to mid-size companies must have a minimum of 15 employee participants. Winners were determined based on a series of over 50 structured workplace questions in core culture categories, including compensation, leadership, professional development, work-life balance, perks and benefits.center_img ©2019 USA Today Distributed by Tribune Content Agency, LLC. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Google, Microsoft and Starbucks are some of the best places to work in the US, workers say (2019, March 29) retrieved 17 July 2019 from https://phys.org/news/2019-03-google-microsoft-starbucks-workers.htmllast_img read more

Missing Interstellar Iron May Just Be Good at Hiding

first_imgInterstellar space should be filled with iron — one of the most common elements in the universe — but scientists have detected only very low amounts of it to date. Now, a new study suggests iron may not be missing, but just really good at hiding. A group of researchers proposes that interstellar iron combines with a certain type of carbon chain to form molecules called iron pseudocarbynes. But because these iron pseudocarbynes register the same signature as carbon molecules on scientists’ detection devices, the sneaky iron remained hidden, according to a statement from Arizona State University (ASU). “We are proposing a new class of molecules that are likely to be widespread in the interstellar medium,” lead author Pilarisetty Tarakeshwar, research associate professor at ASU’s School of Molecular Sciences said in the statement.Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65913-missing-interstellar-iron-found.html?jwsource=cl已复制直播00:0000:3500:35  In the extremely cold temperatures of interstellar space, carbon chains might condense onto iron clusters to form these iron pseudocarbynes, they reported. Over billions of years, the iron pseudocarbynes would combine with other elements and form even more complex molecules. Tarakeshar and his team examined the structure and properties of these molecules in the lab. They used infrared spectroscopy to look at the molecule’s signature spectra, or the pattern of light that gets reflected off from them. “We calculated what the spectra of these molecules would look like, and we found that they have spectroscopic signatures nearly identical to carbon-chain molecules without any iron,” Tarakeshar said. “Previous astrophysical observations could have overlooked these carbon-plus-iron molecules.” What’s more, the iron pseudocarbynes might explain how complex molecules of carbon exist in interstellar space. Carbon chains of more than nine atoms of carbon are unstable, according to the statement. But these iron clusters might be sticking onto them and stabilizing them with their grip. The findings were published on June 26 in the Astrophysical Journal. 11 Fascinating Facts About Our Milky Way Galaxy 15 Amazing Images of Stars In Images: Rising ‘Phoenix’ Aurora and Starburst Galaxies Light Up the Skies Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoSoGoodlyThey Were Named The Most Beautiful Twins In The World, Wait Till You See Them TodaySoGoodlyUndoBeverly Hills MDPlastic Surgeon Tells: “You Can Fill In Wrinkles At Home” (Here’s How)Beverly Hills MDUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndolast_img read more