Wilmington Youth Lacrosse To Hold Fundraiser At Woburns Jake n Joes TODAY

first_imgWOBURN, MA – Looking for an excuse to eat out?Wilmington Youth Lacrosse is holding a fundraiser at Jake n Joes Bar & Grille (230 Mishawum Road) in Woburn on Thursday, May 17, 2018, from 11:30am to close (12:30am Friday).Bring the flyer below and 20% of your bill will be donated to Wilmington Youth Lacrosse. Applies to dine-in and take-out only, not delivery.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWHS Football Team To Hold Fundraiser At Woburn’s Jake ‘n Joes On September 12In “Community”WHS Lacrosse Team To Hold Fundraiser At Woburn’s Jake ‘n Joes On March 5In “Community”WHS Baseball Team To Hold Fundraiser At Woburn’s Jake ‘n Joes On May 31In “Community”last_img read more

Tesla Model Y crossover SUV unveiled

first_img34:37 The success or failure of the Model Y could make or break Tesla. If the vehicle appeals to buyers who hadn’t previously been interested in a sedan like the Model 3 and couldn’t afford a Model X, then it’s all gravy. Of course, that also depends on whether Tesla is able to decide officially where to build it and whether it can build the vehicle without the pronounced quality issues it suffered with the Model 3 (and the Model X and S before it). If Tesla isn’t able to deliver on its promises or the vehicle ends up sharing much less in terms of parts with the Model 3 than expected, then it could go very badly. Based on aesthetics alone, though, that doesn’t look to be an issue. It’s worth remembering, however, that when the Model X was announced, it was supposed to share the bulk of its parts with the Model S, but ended up only sharing around 30 percent. In any case, we now live in a world where Elon Musk has lived out his “S3XY” fantasy and made us all his accomplices in it. We’re looking forward to getting behind the wheel of the Model Y just as soon as we can pry one away from the folks at Tesla, but until then, keep an eye on Roadshow for more Model Y news as it happens. Enlarge ImageHere it is, Tesla’s Model Y, and it looks… pretty much like we expected it to. Tesla Tesla’s Model Y has finally been unveiled to the public, and while the Model 3-based crossover SUV is pretty much what we expected, there’s still a lot here to sink our teeth into. The Model Y has a little bit of a Model X feel about it– including an unexpected optional third-row seating option — minus its big brother’s controversial Falcon doors. Mainly, however, there’s a whole lot of Model 3 DNA and visuals in the 2020 Model Y. In fact, the latter is why it’s arguably Tesla’s least-innovative new vehicle ever. However, that probably doesn’t matter much, and it could actually be a good thing: Given that consumer interest in crossover SUVs is at a fever pitch these days, this new offering is likely to become the brand’s best-selling model when it finally hits the streets late next year. As Musk announced via Twitter recently, Model Y pricing starts at around 10 percent over what a comparably equipped Model 3 does while offering a usable range of approximately 300 miles. This works out to a $39,000 standard-range model, which Musk says is due in 2021, and a long-range model, which will cost $47,000 and go on sale in fall 2020.  What you get in trade is a slightly more family- and cargo-friendly shape and the smug satisfaction that you’ve got the newest Tesla on your block. Plus, given that the Model Y is based on the Model 3, this baby crossover will undoubtedly be pretty quick, as previewed in our early ride-along from Thursday’s reveal event seen below. Tesla Model 3: The one you’ve been waiting for Our first ride in the Tesla #ModelY pic.twitter.com/XLCjI4vGDG— Roadshow (@roadshow) March 15, 2019 Comments Tesla Model 3 Review: Performance trim Tesla pulls the wraps off its Model Y crossover SUV Elon Musk unveils the Tesla Model Y 9 Photoscenter_img Tags Now playing: Watch this: 2019 Tesla Model S Long Range review: Familiar, yet oh so much better Tesla Share your voice More From Roadshow 47 Electric Cars Car Industry SUVs Crossovers Elon Musk Teslalast_img read more

Youths want more jobs environment of tolerance

first_imgDiscussants at the roundtable titled ‘Election 2018: Youth Manifesto’ on Tuesday. Photo: Prothom AloThe young generation of the country wants better employment opportunities and implementation of National Youth Policy for ensuring a sustainable development of both the rural and urban youth, a roundtable was told on Tuesday.Prothom Alo in association with Institute of Informatics and Development (IID) and ActionAid organised the roundtable titled ‘Election 2018: Youth Manifesto’.The new generation also wants a peaceful environment and tolerance towards dissent, observed the participants.Several participants also expressed their hope that the political parties would fully implement the pledges they made in their respective election manifestos announced ahead of the 11th general election.ActionAid country director Farah Kabir lamented the absence of a platform where the young generation can interact with the policy-makers.“The urban upper and upper middle class youth are getting more facilities then the youth in the rural areas. We have to think of the youth in the villages, too,” said Farah.IID chief executive Sayeed Ahmed said the young generation should oversee if the political parties are implementing their manifesto after the election.Northern University’s senior teacher Mahbuba Sultana said young women face different problems when they come to the capital for the first time.The next government should work to eliminate those problems, she added.ActionAid training coordinator Md Nazmul Ahsan urged the political parties to reform the country’s education system to eradicate unemployment.Referring to the laws made following the students’ safe road movement, actress Sabila Noor said the youth want to see implementation of those laws.Student of Bangladesh University of Engineering and Technology Kamruzzaman Kamrul said the universities of the country should increase their allocation on research.He also said the environment to express dissent should exist in the country.Moderated by Prothom Alo associate editor Abdul Quayyum, the roundtable was also addressed by Dhaka University student Jubeli Khanam, North South University student Sharif Ashikuzzaman, Eastern University student Ashrafunnesa Mouri, IID volunteers Aliva Rani Shil, Wahidul Islam, Jarin Tasnim Swarani and Arup Kumar Das, and ActionAid volunteers Md Nasir Uddin and Tasnia Bahar Chowdhury, among others.last_img read more

Alana Robinson DC High School Graduate is a Triple Threat

first_imgAlana RobinsonWhen Alana Robinson closes her eyes, she pictures herself on a Broadway stage in New York City. She dreams of bright lights, musical scores and cheering audiences. As lead senior vocalist for the Duke Ellington Show Choir Ensemble, Robinson dedicates most of her time to singing, dancing and performing. A graduating senior at Duke Ellington School of the Arts, Robinson has performed across the Washington metropolitan area as a vocalist and dancer. However, unlike many of her peers, Robinson regularly leaves the stage for the track, where she competes as a sprinter. She started running to stay in shape for cheerleading, but eventually fell in love with the sport. Because Duke Ellington doesn’t have a track team, Robinson competed as part of the Woodrow Wilson Senior High track team. “Running is something I do to stay level-headed,” she said. “When I’m running, it clears my mind.” Robinson—a key member of Wilson’s 2016 relay team—said the importance of teamwork and communication is transferable from the track to the stage. “They require the same commitment,” she said. “Even though with track, most of the time I’m doing individual races, there’s always a time when we do relays, so I have to get with my team to practice. Her performances with the Ellington choir requires the same team participation. There might be solos here and there, but we’re all still one big group.” Robinson was recently honored as a recipient of the 2015-16 District of Columbia State Athletic Association’s Student-Athlete Scholarship. The scholarship is reserved for student-athletes who lead not only in athletics, but also thrive in the classroom and community. “I think just by virtue of competing in high school athletics, sort of automatically elevates them to some extent in the eyes of their peers,” said the association’s executive director, Clark Ray. “Being able to juggle some demands of school and competitive athletic venture, it just goes hand in hand.” In addition to track and Ellington show choir, Robinson also competes in pageants. She was named first runner-up in the 2015 Miss District of Columbia Teen USA pageant. During summers, she works as a lifeguard at the local pool. Despite juggling a full-time schedule, Robinson was able to maintain a cumulative GPA of 3.31. She will study musical theater at Temple University in the fall, and hopes to continue running in college.last_img read more

8 trains cancelled as BJP workers stage protest at Kankinara

first_imgKolkata: BJP workers and supporters allegedly obstructed train movement at Kankinara, which led to harassment for the daily commuters. Train services were affected for almost half-an-hour which resulted in cancellation of eight local trains during the peak hours on Monday.According to local resident, trouble cropped up on Sunday night when BJP supporters were allegedly putting up flags at ward no. 15 in Bhatpara. It was alleged that the flags were being put up on the house of local councillor Manoj Guha, without his permission. When he asked the BJP workers and supporters not to put up the flags, an altercation ensued between the Guha’s supporters and the BJP men. Also Read – Bose & Gandhi: More similar than apart, says Sugata BoseLater, BJP supporters gheraod Jagaddal police station led by BJP leader Arjun Singh, alleging that Guha had assaulted a BJP supporter. After almost one-and-half-an hour BJP supporters lodged a complaint. A local Trinamool leader denied the allegation and said that BJP is trying to create unrest situation in the area. They are resorting to hooliganism instead of democracy, he said. Situation went out of control when again BJP supporters put up a blockade on Monday morning claiming action over their allegations. Despite repeated requests by the daily commuters, BJP supporters did bother to listen to them. As the protest continued from 9:24 am to 9:50 am, huge numbers of daily commuters were late to their destinations. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataSeveral school and college students also faced trouble. Later, Railway Protection Force and Government Railway Police intervened and managed to convince the BJP supporters to withdraw the blockade. Eastern Railway authorities informed that the train services in Barrackpore-Naihati section of Sealdah Division were affected due to obstruction by a group of people near Kankinara and eight local trains had to be cancelled. Normal train services resumed after 9:50 am.last_img read more

Former police officer sentenced to 43 years for murder

first_imgChetumal, Q.R. — A judge has sentenced a former police officer to more than 43 years in prison.The heavy sentence was handed down Wednesday to a former member of the State Public Security Police. Former officer, Ramón Fernando Caamal Hernández, was sentence to 43 years and nine months in prison for the murder of his wife, Alejandrina MH.Along with his prison sentence, Caamal Hernández was also fined more than 198,000 peso, plus an additional 382,000 peso for damages suffered to a minor as a victim of his crime along with 124,000 peso for the reparation of the quantitative and qualitative damage.Through a statement, the Special Prosecutor for the Care of Crimes against Women and for Gender Reasons confirmed the sentence against Ramón Fernando Caamal Hernández. He was sentenced in a court in the municipality of Othón P. Blanco and was given the highest sentence in the state for the crime of feminicide.The Attorney General of the state says that through the Specialized Prosecutor’s Office for the Attention of Crimes against Women it has already handed out four sentence for the crime of feminicide in less than one year.Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on WhatsApp (Opens in new window)last_img read more

Little boy loses his Slinky toy at Disney World and what happens

first_img ORLANDO — The magic of Disney strikes again, this time for a young boy who lost his beloved toy at Walt Disney World.Wes Ramsaran, who recently embarked on a Walt Disney World vacation with his parents, was devastated after leaving behind his new Slinky dog toy on a park bench. Slinky (of Toy Story fame) was given to Wes by his mother, Kelly Grzech Ramsaran, for being a good listener while on vacation, and was intended to be brought home to join Buzz and Woody in Wes’ toy collection.Facebook: Kelly Grzech RamsaranHowever, while Wes was busying himself with pirate toys inside the gift shop, his father absentmindedly left Slinky on a bench. The family only realized the toy dog was missing on the drive home.In an attempt to get Slinky back (and cheer up her son), Kelly made many phone calls to Disney, eventually connecting with an employee who heard all about the family’s woes. Later that day, another Disney cast member called Kelly to tell her that Slinky had been found and that he would be shipped back to Wes in about 10 days.Facebook: Kelly Grzech RamsaranTrue to their word, Slinky arrived back on their doorstep – with some company. Disney had mailed him back with a bucket of toy soldiers and an additional Woody doll for Wes. Not only that, the package also contained a note from Disney’s Boardwalk Resort Merchandise Team as well as a bunch of photos that highlighted Slinky’s epic adventures while out on his own.More news:  Windstar celebrates record-breaking bookings in JulySlinky was snapped playing video games at the resort, shopping for candy with Woody, driving in a car and visiting stuffed toys at a gift shop. Judging from the pics, it looks like Slinky had just as good a time at Disney World as Wes did!Kelly wrote about the package and posted the photos to Facebook to let others know the lengths Disney will go to bring movie magic to life and make its youngest fans happy. Well done, Disney!Facebook: Kelly Grzech Ramsaran Posted by Little boy loses his Slinky toy at Disney World and what happens next will give you all the feels Thursday, March 22, 2018 Tags: Disneycenter_img Travelweek Group Share << Previous PostNext Post >>last_img read more

Title Insurers Bring in Increased Premiums in Third Quarter

first_img The American Land Title Association (ALTA) “”reports””:http://www.alta.org/press/ALTA_Press_Release_Q3MarketShare.pdf continued improvements for title companies. Each of the three quarters the association reported on so far this year have registered increasing volume for title companies. Premiums rose 28 percent year-over-year in the third quarter. [IMAGE]The industry produced $3 billion in title insurance premiums over the third quarter, up from $2.4 billion during the same period in 2011. “”Title insurance premium volume is highly dependent on real estate sales and mortgage-refinancing activity,”” said ALTA CEO Michelle Korsmo.The Fidelity Family of title insurance underwriters claimed the greatest portion of market share with 33.7 percent. First American Family took the second-largest share with 26.1 percent. [COLUMN_BREAK]Next in line were the Old Republic Family with 13.7 percent and the Stewart Family with 13.6 percent market share. Regional underwriters stepped up to claim 13 percent of the market during the third quarter, an increase from the third quarter of last year when they claimed 11.9 percent. The five states where insurers produced the highest dollar volume in title insurance premiums during the third quarter included California ($440.7 million), Texas ($382.1 million), Florida ($241.9 million), New York ($213.8 million), and Pennsylvania ($130 million). In five states, insurance premiums increased by at least 45 percent in the third quarter when compared with the same quarter last year. Leading this category was North Dakota with an increase of 94.2 percent. The remaining four states include Louisiana (52.9 percent), North Carolina (51.4 percent), Idaho (51 percent), and Nebraska (45.3 percent). The industry as a whole experienced an operating gain of $114 million, up sharply from $16 million in the third quarter last year. This was the result of rising operating income and expenses and falling loss expenses. With $8.7 billion in assets, Korsmo said the title industry is in a “”strong financial position.”” in Data, Government, Origination, Secondary Market, Servicing December 6, 2012 430 Views Title Insurers Bring in Increased Premiums in Third Quartercenter_img Agents & Brokers Attorneys & Title Companies Investors Lenders & Servicers Processing Service Providers Title Insurance 2012-12-06 Krista Franks Brock Sharelast_img read more

Repelect Frederick to help set House GOP policy initiatives

first_img22Dec Rep-elect Frederick to help set House GOP policy initiatives Categories: Frederick News Incoming lawmaker on Action Plan workgroupRep.-elect Ben Frederick of Owosso has been chosen by Speaker-elect Tom Leonard to serve on a special workgroup developing new policy proposals for the 2017-18 House term that begins in January.Rep.-elect Frederick will serve on the Policy Development Workgroup, a team of lawmakers who will study current laws and propose legislative initiatives that the 99th Legislature may consider.“It is an honor to have such an active early role in helping our caucus develop strong public policy initiatives for the coming session,” Rep.-elect Frederick said. “I believe House Republicans should continue to drive Michigan’s comeback by fostering a strong economy, building an environment in which more jobs can be created and reducing government inefficiency.  In particular, I plan to emphasize with my colleagues the need for stronger vocational education opportunities for students, local control within our schools and communities and the importance of preserving a strong agricultural sector. With an action plan in place, we can hit the ground running.”Rep.-elect Frederick will take his seat in the House when session convenes on Jan. 11. The Action Plan was developed to promote transparency in state government. The 2017-18 Action Plan will be publicly unveiled in the coming weeks. The plan also will be available online for review.#####last_img read more

Vivendiowned French service provider SFR is to dr

first_imgVivendi-owned French service provider SFR is to drop its own IPTV service and adopt a partnership model instead, the company has revealed in a communication to union representatives.According to French news channel BFMTV, SFR will team up with Vivendi-owned Canal Plus to provide its TV service. BFMTV cited an SFR source as saying that the company had decided that structuring its own pay TV packages was not profitable and that it would be more lucrative to resell Canal Plus’s service instead.SFR is likely to strike a commercial deal with Canal Plus whereby SFR IPTV subscribers will be offered similar packages from Canal Plus, according to the reports.There has been speculation that Vivendi could sell or spin off SFR. Among options reported to be under consideration are a sale to Vodafone or a merger between SFR and cable operator Numericable.last_img read more

Internet media platform provider Blinkx has launch

first_imgInternet media platform provider Blinkx has launched a dedicated app and open source HTML5-based Blinkx video player for Tizen-based mobile devices.The Blinkx app, available through the Tizen store, will replicate the look and feel of the recently re-launched blinkx.com portal, giving access to over 35 million hours of online video and over 800 media partnerships.Tizen is Linux’s open source software platform for mobile devices. Backed by Samsung and Intel, Tizen released version 2.0 of its platform earlier this year, with Samsung expected to bring devices to market later in 2013.“The blinkx Video Player is an outstanding addition to the Tizen ecosystem and community,” said Christopher Croteau, Tizen Association board member and managing director of Intel’s system software division. “Developers will be able to access the open source HTML5 code and manufacturers utilizing Tizen will be able to more easily include video in mobile devices.”last_img read more

Françoise Nyssen French culture minister Françoise

first_imgFrançoise NyssenFrench culture minister Françoise Nyssen has outlined a series of economy measures and changes to be implemented by public broadcaster France Télévisions as part of the reform of public service media in the country.Youth-oriented channel France 4 will be merged with France 5, which will have a revamped programming line-up to make space for France 4-type shows. At the same time, France Télévisions will focus on making developing a digital-only offering for young people.France 3 will see the amount of regional programming it air trebled from the current two hour daily regional opt-out.Regarding France Ô, the channel dedicated for France’s overseas territories and departments, Nyssen said that it would be necessary to consult with citizens in these territories to determine whether an over-the-air channel or a digital offering would best meet their needs in the future.Nyssen also said that the country’s various public media organisations would have to develop “synergies” and would have to find further economies and rationalise their management. She stopped short of calling for a single management structure or of quantifying the economies she had in mind.Nyssen, quoted by Le Monde, said that she had in mind a “universal” public service media that was capable of resisting “new competition” and responding to citizen’s evolving needs. She said that the goal was to focus “on content more than on distribution”.Nyssen said that France Télévisions would have to invest €150 million more a year in digital as part of a drive to address changing media consumption patterns among young people in particular. She said that the broadcaster currently only invested about 3% of its budget on digital – about €100 million a year.She also said that as part of the drive to further the regionalisation of France 3, the channel would launch a trail of a joint morning programme with radio service France Bleu in two regions in the autumn.On speculation that the digital-terrestrial slot currently occupied by France 4 would be granted to news service Franceinfo, she said that this was a matter for regulator the CSA but noted that the service’s current place in the DTT line-up was “a real handicap” to its visibility.Nyssen said she would commission a task force comprising UniFrance chief Isabelle Giordano, former CSA director-general Frédéric Lenica, Fablabchannel founder Claire Leproust-Moroko, former BBC executive Catherine Smadjia and former France Télévisions president Marc Tessier to take the reform process forward.last_img read more

AN GARDA SIOCHANAbuncranaGARDAI PEOPLE ARE SHELTE

first_img AN GARDA SIOCHANAbuncranaGARDAI: PEOPLE ARE SHELTERING DISSIDENT REPUBLICAN KILLERS OF DERRY MAN ANDREW ALLENLINKS VIEW PARKraad ShareTweet Dissident republican vigilante group RAAD carried out the murder.It claimed the 24-year-old was a drug dealer, a claim rejected by his family.Last September, an inquest into Mr Allen’s murder was adjourned at the request of Gardai.A senior officer told the Coroner that the murder probe was “still a live investigation” Andrew Allen was murdered by dissident vigilante group RAAD in Donegal in February 2012GARDAI say they believe a number of people are sheltering those involved in the murder of a Derry man in Inishowen six years ago.Andrew Allen was killed in front of his partner at his home in Links View Park, Buncrana on February 9, 2012.The 24 year old was shot a number of times and was pronounced dead at the scene. Gardai believe the killers had travelled from Derry to shoot Mr Allen dead.On the eve of the six anniversary of his brutal killing, Gardai have renewed their appeal for information in relation to his murder, and believe that a number of people were involved in the “destruction of evidence.”A silver Vauxhall Cavalier believed to be involved in the murder was found on fire in Fahan shortly after the shooting.There has been a number of arrests in connection with the investigation but nobody has ever been charged.Gardai particularly want to speak to anyone who may have seen suspicious activity around the scene of the shooting or where the burning car was located.A spokesman said: “An Garda Siochana are grateful for all the witnesses that have come forward and made statements but gardai believe that there are still people in both Buncrana and Derry city who have information that may assist with the investigation.”Anyone with information is asked to contact Buncrana Garda Station on 074 93 20540, the Garda Confidential Telephone Line on 1800 666 111 or any garda station.GARDAI: PEOPLE ARE SHELTERING DISSIDENT REPUBLICAN KILLERS OF DERRY MAN ANDREW ALLEN was last modified: February 8th, 2018 by John2John2 Tags:last_img read more

Splat A lucky strike and the telltale red splodge

first_imgSplat! A lucky strike and the telltale red splodge that your nightly tormentor has sucked its last blood vessel.Staring at the mess on the wall, you might find it hard to believe that so small an insect can carry so much blood. But female mosquitoes have a knack for eating, doubling their body weight with each meal.”They can barely fly,” laughs Leslie Vosshall, a neurobiologist at Rockefeller University, who’s hoping to control mosquitoes, as well as the diseases they carry, by switching off their enormous appetite.In a paper published Thursday in the journal Cell, Vosshall and her team demonstrate how human diet drugs satiate mosquitoes’ bloodlust for several days — so they are less likely to feed on humans and spread diseases and will also produce fewer offspring.”When they’re hungry, these mosquitoes are super motivated. They fly toward the scent of a human the same way that we might approach a chocolate cake,” Vosshall says. “But after they were given the drug, they lost interest.”The method taps into female mosquitoes’ natural gluttony. Each supersize meal provides enough nutrients to support the typical clutch of around 100 eggs. After she has eaten, the mosquito loses her appetite for at least four days while her eggs develop.But as soon as a mosquito lays her eggs in a pool of stagnant water, she is off again in search of a mate and a meal. A female mosquito can breed several times in her lifetime of six to eight weeks, and in the process she can bite many people — which makes her a reliable vessel for spreading diseases.Vosshall and her team set out to identify and manipulate the hormone pathways responsible for this behavior. Because similar pathways for hunger are found in many animals — that is, they have similar evolutionary roots — she started with off-the-shelf human diet drugs.”On a lark we thought, ‘Let’s go for it. Let’s do the craziest experiment possible and get some human diet drugs and see if they work on mosquitoes,’ ” Vosshall told NPR.”It was surprising that it worked so well.”In a series of lab experiments, Aedes aegypti mosquitoes (which spread dengue fever, yellow fever and Zika virus) were fed these diet drugs by mixing them into a chemical solution that also contained ATP — a molecule found inside most animal cells that mosquitoes find irresistible. The diet drugs came in powder form. For several days after drinking this solution, the mosquitoes showed little interest when offered the bare arms of human volunteers. Even the smell of dirty nylon stockings, saturated with human scent, was not enough to tempt them.After testing human diet drugs, the team homed in on the specific receptors that these drugs activate inside the mosquito brain. Then they could search through a general catalog of more than 265,000 chemicals to find a new suite of drugs that also activate this receptor — but that control only the appetite of mosquitoes and similar biting insects.”Human drugs are owned by pharmaceutical companies, and so we wanted to find something where the intellectual property wasn’t locked up. That’s important in [developing countries] for deployment,” Vosshall explains. And for obvious reasons, widely releasing human diet drugs into the environment is not a good idea.In recent years, scientists have developed an advanced arsenal of tools in the war against mosquitoes — from potent new insecticides to gene drives and bacterial infection. But rarely have they tried to control mosquitoes’ behavior.”There is a real need for novel approaches to controlling insects that transmit diseases,” says James Logan of the London School of Hygiene & Tropical Medicine, who was not involved in the study.According to the World Health Organization, mosquito-borne diseases — such as malaria, yellow fever, dengue and Zika virus — are responsible for millions of deaths each year.”Humans have been trying to fight mosquitoes ever since there were humans,” says Vosshall, pointing to an impressive variety of control methods — from rolled-up newspapers to genetic engineering.”All of these advances are complementary,” says Vosshall, who argues that no single innovation can eradicate mosquito-borne diseases and advocates using several methods at once. “Our behavior control is something else in this portfolio,” she says.This strategy seeks to reduce mosquito numbers rather than annihilate the insects entirely, which could have unintended ecological consequences. “I do worry about the balance of nature,” Vosshall says.But not everyone agrees that eradicating mosquitoes is a bad idea. “A recent study suggested that malaria mosquitoes do not play a vital role in the ecosystem, and therefore their removal would have minimal impact,” Logan says.”I don’t think we will ever eradicate all mosquitoes. But I do think that one day we will eradicate individual species,” he says.It’s early days for this novel approach to mosquito control, and it remains unclear how substantially it would stem the spread of disease in the real world. Meanwhile, more lab research must be done to develop these drugs so that they are potent and cheap enough to use in the field.”Transitioning from laboratory experiments to the field is always difficult,” Logan says. “One of the biggest challenges will be devising a system that attracts mosquitoes well enough and allows them to feed on this substance effectively.””You need to have dispensers; you need some way to attract female mosquitoes and have that work in local communities,” says Vosshall, looking to the logistical hurdles ahead.Putting billions of mosquitoes on an unwitting diet was never going to be easy.Thomas Lewton is a freelance science journalist and videographer who divides his time between London and Kampala, Uganda. You can follow him on Twitter: @thomaslewton. Copyright 2019 NPR. To see more, visit https://www.npr.org.last_img read more

Mark Zuckerberg Gives a Lesson in How Not to Lead in a

first_img Opinions expressed by Entrepreneur contributors are their own. Facebook 2019 Entrepreneur 360 List Next Article Guest Writer April 3, 2018 Image credit: NurPhoto | Getty Images Add to Queue Zuckerberg is renowned for inventing Facebook, but his reputation for leading it is in tatters. Samuel Edwards Mark Zuckerberg Gives a Lesson in How Not to Lead in a Crisis 5 min read Digital Marketing Strategist –shares Apply Now » The only list that measures privately-held company performance across multiple dimensions—not just revenue. For a while, Facebook could do no wrong. All you have to do is take a quick look at the Facebook stock chart and you’ll see a company that has watched its value rise nearly 500 percent over the past five years alone. But that same chart will also show you a hefty decline since the middle of March. In all honesty, CEO Mark Zuckerberg is to blame. Cambridge Analytica exposed Zuckerberg’s greatest flaw.It would be safe to say that public trust in Facebook is at an all-time low. If the past year has taught us anything, it’s that trust must be continually cultivated, no matter how much of it you think your organization has.Perhaps it was an inflated sense of public trust, an attitude of invincibility, or an unwillingness to own up to responsibility that led Zuckerberg, COO Sheryl Sandberg and other Facebook executives to take a painfully long time to formulate a response to the news that data firm Cambridge Analytica gained access to millions of its users’ data three years ago. However, at this point, does it really matter? The problem is that Facebook is developing a poor track record of managing crises.Now that people know just how much of their personal data Facebook has, the last thing the company can afford is for people to view the social network giant as being irresponsible. Unfortunately, Zuckerberg’s response in the wake of this crisis has done little to instill confidence and accountability.Zuckerberg and the company must decide whether they’re going to embrace the responsibility they have. They’ve walked into this mess by amassing mounds of personal information on users. If they don’t want to deal with the responsibility that comes with it, they need to step out of the way. That’s the blunt truth.To Zuckerberg’s credit, he finally spoke up. “I’ve been working to understand exactly what happened and how to make sure this doesn’t happen again,” Zuckerberg wrote in a post on his profile. “I promise you we’ll work through this and build a better service over the long term.”Zuckerberg’s response was, arguably, another poor PR move. He said no more than you’d expect but far later than he should have. Plus, it was sterile and vague. He left many wondering if Facebook is really doing enough to protect user data.Related: Read Mark Zuckerberg’s Full Statement on Facebook’s Data ScandalTakeaways from Facebook’s PR debacle.Taking your personal feelings and data out of the equation, the Facebook-Cambridge Analytica crisis has been a textbook PR case study in what not to do. As we look at it in more detail, here are a few of the takeaways and lessons business owners and entrepreneurs should spend some time studying.1. Don’t delay.The issue most people had with Facebook’s response was that it took so long for one to be formulated and publicized. Since the company obviously was aware of what was going on, it was unacceptable and disingenuous to keep people waiting for days.One of the first rules of good crisis management is to get ahead of the problem. The sooner you can address the issue, the better you can shape the public narrative and response.Related: Read the Controversial 2016 Facebook Memo in Which an Exec Argues for ‘Growth at Any Cost’2. Apologize.Zuckerberg’s eventual response was 936 words long. While it contained a bunch of corporate language and legal jargon, do you know what word was completely missing? The simple word sorry.It’s not always necessary to spend a bunch of time apologizing in the wake of a crisis, but you do need to say sorry — even if the incident was largely outside your control. It humanizes your brand and makes you look like you care.Related: Mark Zuckerberg Doesn’t Seem Very Sorry or Very Forgiven3. Act.The final lesson is to take action. If you say you’re going to do something, make sure your actions follow your speech. While it remains to be seen if Facebook will maintain a stiffer posture on responsibly stewarding user data, there has been some initial activity.Zuckerberg recently posted to his Facebook page that new privacy and security settings have been placed at the top of everyone’s Newsfeed so that users can easily disable apps they are no longer using and tweak their security settings to fit their preferences. If nothing else, it’s a start.Related: Facebook’s Data Scandal and Europe’s New Data Privacy Rule Have Massive Implications for U.S. EntrepreneursFor Zuckerberg and Facebook, the good news is there will be plenty of opportunities to rebuild trust with users. However, if they’re going to restore that trust, they must learn from their mistakes and make it a point to improve their crisis management efforts and address the PR shortcomings they’ve repeatedly been characterized by. As an outsider looking in, you can also learn from their mistakes and prepare your own business for handling crises with more grace.last_img read more

Richard Branson Says the 95 Workday Grind Is About to Die Heres

first_img Richard Branson Says the 9-5 Workday Grind Is About to Die. Here’s Why. –shares 2 min read Learn how to successfully navigate family business dynamics and build businesses that excel. Nina Zipkin Register Now » Image credit: Axelle/Bauer-Griffin | Getty Images December 19, 2018 Richard Branson believes the 5-day, 9-5 work week will eventually become extinct.In a recent blog post, the Virgin Group founder cited a familiar argument, that technological innovation — especially advances that do away with the need for people to operate everything from factory machinery to cars and planes — will change work as we know it.But he writes that this doesn’t necessarily have to be something to fear. Instead it can be an opportunity to shake things up for the better, and to accelerate the creation of smarter working practices for everyone.Related: Advice for Elon Musk From Richard Branson, Arianna Huffington and Mark Cuban“One useful idea is for governments to provide tuition for workers to gain the technical skills needed in the new marketplace, in exchange for public service. We need more creative solutions too,” Branson explains.Two other ideas that Branson supports are the proliferation of three and four day weekends and job sharing. These would prioritize a work infrastructure that allows employees to have full lives outside of an office, to spend time with friends and family, to  devote time to the things they are passionate about, and to focus on being physically and mentally healthy.Branson explained how flexible work is a big part of how he leads Virgin Group. “If you trust people and treat them as adults, they will repay you by working effectively and efficiently,” he wrote. “Choice can empower people to make good decisions and feel positive about their workplace, helping to keep great employees and attract new talent. If we all work smarter, we won’t have to work longer.”center_img Work-Life Balance Add to Queue The Virgin Group founder urges businesses to implement flexible work practices to get the most from their employees. Staff Writer. Covers leadership, media, technology and culture. Free Webinar | July 31: Secrets to Running a Successful Family Business Next Article Entrepreneur Stafflast_img read more

Regions Bank Taps IBMs AI to Power Next Generation Customer Service

first_imgWatson Has Helped Regions Answer over 1.5 Million Customer Calls and 1.4 Million Banker QuestionsIBM announced that Regions Bank has selected the company’s artificial intelligence (AI) technology to help improve customer service and assist bankers in everyday work.In today’s digital world, the customer experience remains paramount. A staggering 62% of banking customers will consider switching to a competitor after only 1-2 bad experiences, and more than 90% of customers share details about bad experiences with others. Customer service professionals know that most questions don’t always require long troubleshooting. Agents spend their time answering similar questions, rather than focusing on more complex, exceptional cases.To ensure a positive customer experience, Regions Bank is using Watson in its contact centers to help both customers and employees. The company’s Banker Assist harnesses Watson Assistant to provide bankers with guidance on customer inquiries, enabling them to resolve customer service needs faster. With Banker Assist, employees can use AI-powered search when faced with a question to provide quicker call resolutions and more consistent answers. Already, 700 professionals at the bank rely on Watson to complete customer problem resolution.Marketing Technology News: Pagely Announces 2nd Annual Scholarship for Underrepresented Students in TechAdditionally, when customers call Regions, many interact directly with Watson Assistant receiving rapid and consistent answers to their questions. They can get help on a variety of issues including updating personal information and navigating the Regions Bank website. Letting Watson take on the more routine questions allows service representatives to tackle the more intellectually challenging questions, spend more time engaging with customers and be better informed to resolve issues. Over time, Watson will be trained on other tasks, including analyzing customers’ tone to help determine when a customer should be transferred to a live agent.Our Resources: How Connected Workplaces Can Help You Unlock Higher Levels of Productivity“At Regions we are investing in technology to make banking easier for our customers and to recruit and retain talented associates,” said Chris Brasher, head of Bank Operations for Regions Bank. “IBM Watson’s automated intelligence is an important tool that allows us to operate more effectively by understanding customer needs. We are identifying additional use cases for this technology as part of our focus on continuous improvement across the company.”Marketing Technology News: New Research from Fresh Relevance Highlights Impact and Adoption of Influencer Marketing Is Overestimated“The use of artificial intelligence among banks continues to rise, helping financial institutions make better use of vast amounts of data, analyze patterns, evaluate risks and improve customer service,” said Beth Smith, General Manager, IBM Watson AI. “Regions Bank is focused on improving customer and associate relationships and Watson will help them continue to provide a great customer experience.”Marketing Technology News: PX Open Marketplace Surpasses 500 Publishers in its Exchange Regions Bank Taps IBM’s AI to Power Next Generation Customer Service PRNewswireApril 26, 2019, 5:44 pmJuly 16, 2019 Artificial Intelligencecustomer experienceIBMMarketing TechnologyNewsRegions Bank Previous ArticleLINK Mobility to Integrate With Oracle ResponsysNext ArticleNew Yotpo and Klaviyo Integration Propels Email Innovation and Revenues for D2C Brandslast_img read more

Neuroene Therapeutics receives 15 million NIH grant to develop antiseizure compound for

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Oct 29 2018Neuroene Therapeutics, a start-up company founded by mitochondrial biologist Sherine S. L. Chan, Ph.D. and medicinal chemist C. James Chou, Ph.D. of the Medical University of South Carolina, has received a $1.5 million NIH Phase II Small Business Innovation Research grant to optimize vitamin K analogues that could improve seizure control in patients with drug-resistant epilepsy. Richard Himes, Ph.D., a chemist at the College of Charleston, serves as the company’s Chief Scientific Officer.Of the 3.4 million Americans estimated to have epilepsy, one third do not receive adequate seizure control with current medications, either because the drugs do not work for them or because they cannot tolerate the drug’s side effects.The SBIR grant will enable Neuroene Therapeutics to test the efficacy and safety of its lead compounds, which are analogues of a naturally occurring form of vitamin K that is essential for mitochondrial and neuronal health.”Mitochondria are the powerhouses of the cell, and the brain needs a lot of energy for its function. A particular form of vitamin K protects the integrity of the mitochondria and helps them produce enough energy for brain cells,” explained Chan.The form of vitamin K needed by the brain is not the same as the vitamin K we get from foods in our diet. The vitamin K we eat must first be processed by intestinal bacteria before transport to the brain, and then within neurons must be converted into the specific form of Vitamin K that is needed for mitochondrial and neuronal health.Because the compound developed by Neuroene Therapeutics mimics this specific form of Vitamin K that the neuron needs (not the ingested form) and because it travels directly to the brain, it bypasses the need for transport systems.”Unlike other vitamin K analogues, which require additional processing before they are in a usable form, our compounds are a direct substitute for the active form and go directly to the brain where they are needed,” said Chou.Related StoriesResearchers discover biochemical agent responsible for blood pressure drop in sepsisCompound derived from broccoli sprouts may restore brain chemistry imbalance related to schizophreniaCopper compound with potential as therapy for ALS shows further promiseEarly testing of these vitamin K analogues by the MUSC investigators with pilot funding from the South Carolina Clinical and Translational Research Institute, a Clinical and Translational Science Awards hub funded by the National Institutes of Health, showed significantly reduced seizure activity with little toxicity in a zebrafish model. Testing in mouse seizure models at the National Institute of Neurological Disorders and Stroke Anticonvulsant Screening Program confirmed those findings.With assistance from the MUSC Foundation for Research Development, Chan and Chou established Neuroene Therapeutics in 2015 and received a patent on their lead compounds earlier this year.The current SBIR award will enable additional testing of the compounds’ efficacy and safety at the University of Utah’s Anticonvulsant Drug Development Program, directed by Karen Wilcox, Ph.D., which has robust rodent models of drug-resistant epilepsy. By the end of the two years of SBIR funding, Neuroene Therapeutics will have identified the lead compound to take forward into clinical trial.Although Neuroene Therapeutics is focused currently on developing its lead compound for drug-resistant epilepsy, Chan and Chou are also studying whether vitamin K analogues could improve outcomes in other difficult-to-treat neurological diseases. They already have some promising preclinical data in Parkinson’s disease and mitochondrial DNA depletion syndrome. In addition, they speculate that the compounds could also be relevant to Alzheimer’s disease.Apolipoprotein E4, one of the strongest genetic risk markers for late-onset Alzheimer’s disease, has a role to play in vitamin K transport. It is possible, then, that mitochondrial dysfunction due to insufficient transport of vitamin K could be implicated in Alzheimer’s and, if so, these brain-penetrating vitamin K analogues could bypass the transport process, thus improving mitochondrial health and disease outcome. Source:http://www.musc.edulast_img read more

Study reveals immune evasion strategy developed by cytomegaloviruses

first_img Source:https://www.plos.org Apr 8 2019Owl monkey cytomegalovirus produces a decoy molecule A43 to evade detection and destruction by immune cells in their hosts, according to a study published April 4 in the open-access journal PLOS Pathogens by Ana Angulo of the University of Barcelona, and colleagues. As the authors note, the findings provide a novel example of an immune evasion strategy developed by viruses. An ingenious viral immune evasion tactic used by the CMV protein A43. Credit: Maria AnguloRelated StoriesNew protein target for deadly ovarian cancerMother calls for protein shake regulation after daughter diesHinge-like protein may unlock new pathways for cystic fibrosis treatmentThroughout evolution, cytomegaloviruses (CMVs) have been capturing genes from their hosts, employing the derived proteins to dampen immune responses and successfully persist within their hosts. Certain CMVs encode homologs of CD48, a molecule found on the surface of most of the leukocytes of the body. CD48 binds to the 2B4 receptor on certain immune cells such as natural killer cells, which play a pivotal role in the rapid recognition and control of viral infections. But the properties and biological relevance of the viral CD48 homologs have not been explored. In the new study, Angulo and colleagues have investigated for the first time the immunomodulatory potential of one of these viral molecules: A43, a CD48 homolog encoded by owl monkey CMV.The researchers show that A43 binds strongly to 2B4 and is capable of blocking its interaction with CD48. Moreover, the findings reveal how this viral protein interferes with the function of human natural killer cells. Taken together, these results not only underscore the importance of 2B4-mediated immune responses in controlling CMV infections, but also unveil CD48 as a new viral counteract mechanism for subverting immune surveillance. The authors propose that A43 may serve as a CD48 decoy receptor by binding and masking 2B4, thereby impeding effective immune control by cytotoxic lymphocytes during viral infections. According to the authors, the research highlights the potential of using the inhibitory molecule A43 to develop novel therapeutic tools to manipulate aberrant immune responses, such as those linked to autoimmune diseases.last_img read more

Joey Barton charged with actual bodily harm after Barnsley incident

first_imgOn April 18, he tweeted: “With regards to the alleged incident on Saturday following our game against Barnsley, I emphatically deny all the allegations made.”Given this matter has not been formally closed, it would be inappropriate for me to make any further comment.”Barton, who had spells with Manchester City and Newcastle United during his playing career, guided Fleetwood to 11th in League One last season, his first in charge. Fleetwood Town manager Joey Barton has been charged with actual bodily harm following an incident at his side’s match against Barnsley at Oakwell in April. An SYP statement read: “On Saturday 13 April 2019, a man was left with facial injuries after an incident in the club tunnel around 5pm, following the conclusion of Barnsley’s match against Fleetwood Town.”Barnsley lodged a formal complaint to the English Football League and Football Association following the incident and assisted with police enquiries.MORE: Channel Seven’s coverage woes continue in Man Utd’s clash with LeedsBarton duly denied allegations he had assaulted Barnsley boss Daniel Stendel.center_img South Yorkshire Police (SYP) confirmed Barton, 36, has been bailed to appear before Barnsley Magistrates Court on October 9.last_img read more