07Feb Representative García: Grant essential for Ottawa County veteran services Categories: Garcia News Today state Representative Daniela R. García (R-Holland) cosponsored legislation that would develop a new grant program encouraging Michigan counties to develop veteran service offices.Under this legislation, each county with a veteran service office that satisfies pre-approved requirements would receive $25,000, plus an additional amount based on the number of veterans in the county. To continue receiving the grant, an established county veteran service office must meet benchmarks for staff performance and reporting while maintaining the previous year’s funding level.“It’s important for Michigan to invest in local veteran service offices,” García said. “Investing funds into counties will increase veterans’ access to the necessary assistance they may need.”Under the current veteran’s benefits system, the state supplies the Veteran Service Coalition with a grant to provide benefit services to veterans. Depending on the county, a Veteran Service Officer may only be available for a few hours each month at a single location. This bill provides incentives to counties to develop or enhance a tool for providing sufficient services for veterans.“This grant is a great opportunity for making sure counties have the tools to properly take care of Michigan’s veterans.” García added, “With this legislation, we will be moving our state in the right direction when it comes to providing more options and greater access for veteran services across the state.”The measure, House Bill 5536, will be formally read into the record Thursday.
Internet media platform provider Blinkx has launched a dedicated app and open source HTML5-based Blinkx video player for Tizen-based mobile devices.The Blinkx app, available through the Tizen store, will replicate the look and feel of the recently re-launched blinkx.com portal, giving access to over 35 million hours of online video and over 800 media partnerships.Tizen is Linux’s open source software platform for mobile devices. Backed by Samsung and Intel, Tizen released version 2.0 of its platform earlier this year, with Samsung expected to bring devices to market later in 2013.“The blinkx Video Player is an outstanding addition to the Tizen ecosystem and community,” said Christopher Croteau, Tizen Association board member and managing director of Intel’s system software division. “Developers will be able to access the open source HTML5 code and manufacturers utilizing Tizen will be able to more easily include video in mobile devices.”
Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 29 2018Neuroene Therapeutics, a start-up company founded by mitochondrial biologist Sherine S. L. Chan, Ph.D. and medicinal chemist C. James Chou, Ph.D. of the Medical University of South Carolina, has received a $1.5 million NIH Phase II Small Business Innovation Research grant to optimize vitamin K analogues that could improve seizure control in patients with drug-resistant epilepsy. Richard Himes, Ph.D., a chemist at the College of Charleston, serves as the company’s Chief Scientific Officer.Of the 3.4 million Americans estimated to have epilepsy, one third do not receive adequate seizure control with current medications, either because the drugs do not work for them or because they cannot tolerate the drug’s side effects.The SBIR grant will enable Neuroene Therapeutics to test the efficacy and safety of its lead compounds, which are analogues of a naturally occurring form of vitamin K that is essential for mitochondrial and neuronal health.”Mitochondria are the powerhouses of the cell, and the brain needs a lot of energy for its function. A particular form of vitamin K protects the integrity of the mitochondria and helps them produce enough energy for brain cells,” explained Chan.The form of vitamin K needed by the brain is not the same as the vitamin K we get from foods in our diet. The vitamin K we eat must first be processed by intestinal bacteria before transport to the brain, and then within neurons must be converted into the specific form of Vitamin K that is needed for mitochondrial and neuronal health.Because the compound developed by Neuroene Therapeutics mimics this specific form of Vitamin K that the neuron needs (not the ingested form) and because it travels directly to the brain, it bypasses the need for transport systems.”Unlike other vitamin K analogues, which require additional processing before they are in a usable form, our compounds are a direct substitute for the active form and go directly to the brain where they are needed,” said Chou.Related StoriesResearchers discover biochemical agent responsible for blood pressure drop in sepsisCompound derived from broccoli sprouts may restore brain chemistry imbalance related to schizophreniaCopper compound with potential as therapy for ALS shows further promiseEarly testing of these vitamin K analogues by the MUSC investigators with pilot funding from the South Carolina Clinical and Translational Research Institute, a Clinical and Translational Science Awards hub funded by the National Institutes of Health, showed significantly reduced seizure activity with little toxicity in a zebrafish model. Testing in mouse seizure models at the National Institute of Neurological Disorders and Stroke Anticonvulsant Screening Program confirmed those findings.With assistance from the MUSC Foundation for Research Development, Chan and Chou established Neuroene Therapeutics in 2015 and received a patent on their lead compounds earlier this year.The current SBIR award will enable additional testing of the compounds’ efficacy and safety at the University of Utah’s Anticonvulsant Drug Development Program, directed by Karen Wilcox, Ph.D., which has robust rodent models of drug-resistant epilepsy. By the end of the two years of SBIR funding, Neuroene Therapeutics will have identified the lead compound to take forward into clinical trial.Although Neuroene Therapeutics is focused currently on developing its lead compound for drug-resistant epilepsy, Chan and Chou are also studying whether vitamin K analogues could improve outcomes in other difficult-to-treat neurological diseases. They already have some promising preclinical data in Parkinson’s disease and mitochondrial DNA depletion syndrome. In addition, they speculate that the compounds could also be relevant to Alzheimer’s disease.Apolipoprotein E4, one of the strongest genetic risk markers for late-onset Alzheimer’s disease, has a role to play in vitamin K transport. It is possible, then, that mitochondrial dysfunction due to insufficient transport of vitamin K could be implicated in Alzheimer’s and, if so, these brain-penetrating vitamin K analogues could bypass the transport process, thus improving mitochondrial health and disease outcome. Source:http://www.musc.edu
Source:https://www.chla.org/ Reviewed by James Ives, M.Psych. (Editor)Nov 30 2018Many factors affect cancer treatment outcome, such as the size and location of the tumor, availability of effective treatments, and timing of intervention. But some cancers are so aggressive that outcome is poor, even after early diagnosis and chemotherapy. Researchers have focused their attention on trying to understand what makes some cancers less treatable than others. Now, researchers at Children’s Hospital Los Angeles reveal a mechanism by which some cancers trick healthy cells into protecting tumors.Yves DeClerck, MD, of the Children’s Center for Cancer and Blood Diseases and the Saban Research Institute at Children’s Hospital Los Angeles, has dedicated his career to understanding how cancer cells interact with the surrounding normal tissue to escape the effects of therapy. Research has shown that tumors with high levels of a protein called Plasminogen Activator Inhibitor 1 (PAI-1) are more aggressive and are associated with poorer outcomes. In the new study, published November 20th in the journal Cell Reports, DeClerck’s team demonstrated that cancer cells use PAI-1 to trick the body’s immune system into supporting the cancer.DeClerck and his team, led by postdoctoral research fellow Marta Kubala, PhD, characterized a relationship between tumors and the immune system. “In this study, we focused on the role of immune cells called macrophages and how PAI-1 affects their activity,” explains Kubala. As important players in the immune system, macrophages find and destroy cancer cells or foreign invaders like bacteria. While macrophages are normally considered anti-cancer, DeClerck’s team showed that PAI-1 pushes macrophages into an alternate, pro-cancer state (called M2) by recruiting common players in the immune system – IL-6 and STAT3 – effectively signaling to the macrophages to support rather than attack tumor cells.”A macrophage can either be a friend or an enemy to cancer cells,” explains DeClerck, who is also a professor of pediatrics at the Keck School of Medicine of the University of Southern California. “The cancer communicates with the macrophages, telling them to become friendly. So, the macrophages change their behavior and support the tumor.” In altering the function of surrounding, healthy tissue, the cancer is better able to survive and spread.Related StoriesSugary drinks linked to cancer finds studyMother calls for protein shake regulation after daughter diesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe team around DeClerck also shows that cancer cells can use PAI-1 to promote movement of these pro-cancer M2 macrophages into the tumors, where they protect the cancer and repair any damage that chemotherapy may have inflicted. This symbolic one-two punch culminates in a stronger, more difficult-to-treat cancer.DeClerck and his team have uncovered what appears to be a very common mechanism used by many cancers to commandeer part of the body’s immune system. In order to investigate how broadly this cellular communication could impact cancer treatment, DeClerck’s team studied the National Institute of Health’s Cancer Genome Atlas, a library of genetic information from more than 11,000 patient samples, and found that many different cancers have this relationship. “We looked at patient data from neuroblastoma and breast, prostate, colon, and lung cancers. Every time we see higher levels of PAI-1, we see more evidence of pro-cancer M2 macrophages,” says DeClerck.This new understanding of just how PAI-1 communicates with macrophages to change their activity has the potential to alter our approach to cancer treatment since these findings are applicable to most types of cancer. “It is clear that the tumor microenvironment, including cells of the immune system, is crucial in cancer development,” explains Kubala.While cancers vary widely in terms of location, treatment, and survival rates, their manipulation of macrophages represents a common thread, which is important for devising improved treatments for aggressive cancers. “Targeting PAI-1 could be beneficial in cancer,” DeClerck says, “but much more work needs to be done.” He cautions that the answer is not as simple as eliminating PAI-1, which is also made in healthy tissue and is an important part of the blood clotting process. But these results, which uncover a complete pathway of communication between tumors and macrophages, lay the foundation for a promising avenue of research.
Credit: Tatiana Vdb, Flickr Jul 3 2019The longer a pregnancy continues past 37 weeks gestation, the higher the risk of a stillbirth, according to a new meta-analysis published this week in PLOS Medicine by Shakila Thangaratinam of Queen Mary University of London, UK, and colleagues. Related StoriesScientists study immune molecules inside mycetoma grainsIncreasing awareness about visceral leishmaniasis could help reduce fatalities, disease transmissionNew computational modeling method predicts how gut microbes change over timeOf the 3000 babies stillborn every year in the UK, a third appeared healthy at 37 weeks. In the new work, researchers searched major electronic databases for studies on term pregnancies that included weekly numbers of stillbirths or neonatal deaths. Thirteen studies, providing data on 15 million pregnancies and 17,830 stillbirths, were identified and included in their analysis.The risk of stillbirth increased with gestational age from 0.11 stillbirths per 1000 pregnancies at 37 weeks (95% CI 0.07 to 0.15) to 3.18 stillbirths per 1000 pregnancies at 42 weeks (95% CI 1.84 to 4.35). From 40 to 41 weeks, there was a 64% increase in the risk of stillbirth. Neonatal mortality remained steady in babies born from 38 to 41 weeks, but was significantly higher for babies born at 42 weeks compared to 41 weeks (RR 1.87, 95% CI 1.07 to 2.86, p=0.012).“Any mother considering prolongation of pregnancy beyond 37 weeks should be informed of the additional small but significantly increased risks of stillbirths with advancing gestation,” the authors say. “There is a need to assess the acceptability of early delivery at term to parents and healthcare providers to avoid the small risk of stillbirth. Better stratification of apparently low risk women for complications using individualized prediction models could reduce the number of women who need to be delivered to avoid one additional stillbirth.” Source:PLOSJournal reference:Khalil, A. et al. (2019) Risks of stillbirth and neonatal death with advancing gestation at term: A systematic review and meta-analysis of cohort studies of 15 million pregnancies. PLOS Medicine. doi.org/10.1371/journal.pmed.1002838.
Explore further © 2018 AFP French carmarker PSA Peugeot Citroen said Tuesday its acquisition of the Opel and Vauxhall brands last year helped drive sales up more than 42 percent in the first quarter. French carmaker PSA says global sales up 15% in 2017 The auto giant said it had seen a growth in sales volume around the world, “with a record 1.05 million cars sold”.As such the company is likely to surpass its expectations of selling four million cars in 2018, as announced by CEO Carlos Tavares in March.PSA last year became Europe’s second biggest carmaker after Volkswagen when it bought Vauxhall and German brand Opel from US giant General Motors.It said revenue jumped 42.1 percent to 18.2 billion euros ($22.2 billion) from January to March this year.Excluding last summer’s acquisition of Opel Vauxhall, Peugeot, Citroen and premium brand DS saw revenue surge 13.3 percent to 10.2 billion euros in the first quarter.Tavares had also promised better sales on the Chinese market, which had been PSA’s weak spot and where sales had dipped 37 percent last year.In the first three months of 2018, the company’s fortunes in China began to shift, with a slight increase in sales of 1.8 percent.Of the company’s brands, Citroen was the best performing in China, the world’s biggest car market, while DS sales dropped nearly 58 percent in the Asian giant.In Europe, which is by far the company’s biggest market, sales jumped 8.7 percent, thanks mainly to Peugeot.Taking into account the figures for Opel Vauxhall in Europe, sales jumped 65.7 percent to over 770,000 units. Opel Vauxhall continues to weigh on profitability, however, even as PSA presses on with a major plan to turn around its results.”Push to Pass strategic plan and Opel Vauxhall turnaround plan are on track to make this strong performance a solid basis for the future,” chief financial officer Jean-Baptiste de Chatillon said. PSA’s results were doped by the inclusion of Opel Vauxhall in its books Citation: PSA Peugeot Citroen rides to higher sales, backed by Opel Vauxhall (2018, April 24) retrieved 18 July 2019 from https://phys.org/news/2018-04-psa-peugeot-citroen-higher-sales.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Facebook, Starbucks, Ernst & Young are among top U.S. companies for professional development Let’s face it, some jobs are just better than others. The best companies to work for are headed by effective leaders. They offer competitive salaries, opportunities for advancement, payroll bonuses, health insurance and other useful perks that enhance your quality of life outside the office.Which U.S. companies offer all that and more?The compensation, culture and career monitoring website Comparably.com ranked them by region using data collected from 10 million employee ratings and thousands of salary records.Highspot, a sales software platform, took the top spot in Seattle and Google beat out all the Silicon Valley and San Francisco companies. Hubspot, a software marketing service, was the best in the Boston area, according to workers.The software company Workfront leads the pack in the Salt Lake City area. The business process outsourcing firm TaskUs is the top company in the Los Angeles region. UiPath, an automation vendor, is the best company to work for in the New York area.Comparably asked workers questions in 20 culture categories including work-life balance, compensation, professional development and leadership.”What stands out is that these are the best companies across all those categories,” said Comparably’s CEO and founder Jason Nazar. The list is “breaking down how a company is performing to its workers, how happy people are with their pay, and what they think about their team members and managers.”Comparably organized the winners by region since most companies are vying for the best talent on a local level, according to Nazar. The list is also useful for workers who are seeking employment within a specific market “regardless of company size,” Nazar said.The winners range from startups with a few employees to Fortune 50 businesses with more than 500 staff members.”Employees are expecting the best of both worlds,” Nazar said. “They want earlier stage companies to offer the same benefits that they’d get at large-scale companies. At large companies, they want the flexibility and ownership that they’d get in smaller companies.” Explore further Best places to work in Seattle regionHighest ranked 1. Highspot (Seattle) 2. Edifecs (Bellevue, Washington) 3. T-Mobile (Bellevue, Washington) 4. Microsoft (Redmond, Washington) 5. Costco (Issaquah, Washington) 6. Akvelon (Bellevue, Washington) 7. Starbucks (Seattle) 8. Hiya (Seattle) 9. Karat (Seattle) 10. RealSelf (Seattle) 11. Shyft Technologies (Seattle) 12. Amazon (Seattle) 13. Zipwhip (Seattle) 14. Porch.com (Seattle) 15. Liquid Planner (Seattle)Best places to work in Los AngelesHighest ranked 1. TaskUs (Santa Monica, California) 2. PeerStreet(Los Angeles) 3. Acorns (Irvine, California) 4. Barry’s Bootcamp (Los Angeles) 5. Golden Hippo (Woodland Hills, California) 6. InvestCloud (West Hollywood, California) 7. Blizzard Entertainment (Irvine, California) 8. Chrome River Technologies (Los Angeles) 9. Signal Sciences (Los Angeles) 10. SmartBug Media (Newport Beach, California) 11. FaceFirst (Los Angeles) 12. Seek Capital (Los Angeles) 13. Tinder (Los Angeles) 14. CornerStone On Demand (Santa Monica, California) 15. BQE Software (Torrance, California)Best places to work in Boston regionHighest ranked 1. HubSpot (Cambridge, Massachusetts) 2. Drift (Boston) 3. LogMeIn (Boston) 4. Drizly (Boston) 5. Dynatrace (Waltham, Massachusetts) 6. Celtra (Boston) 7. Notarize (Boston) 8. Jabra (Boston) 9. Acquia (Boston) 10. Buildium (Boston) 11. ConnectRN (Waltham, Massachusetts) 12. Pegasystems (Cambridge, Massachusetts) 13. ClearGov (Maynard, Massachusetts) 14. Liberty Mutual Insurance (Boston) 15. TaxJar (Woburn, Massachusetts)Best places to work in San Francisco/Silicon ValleyHighest ranked 1. Google (Mountain View, California) 2. Sitetracker (Palo Alto, California) 3. Salesforce (San Francisco) 4. Upgrade (San Francisco) 5. Nevro (Redwood City, California) 6. Sunrun (San Francisco) 7. Periscope Data (San Francisco) 8. Infrrd (San Jose, California) 9. Globant (San Francisco) 10. Intuit (Mountain View, California) 11. Sonder (San Francisco) 12. LinkedIn (Sunnyvale, California) 13. TripActions (Palo Alto, California) 14. Mixpanel (San Francisco) 15. Asana (San Francisco)Best places to work in New York regionHighest ranked 1. UiPath (New York) 2. CultureIQ (New York) 3. Greenhouse Software (New York) 4. Overtime (Brooklyn) 5. WhiteSource (New York) 6. International Flavors & Fragrances (New York) 7. ADP (Roseland, New Jersey) 8. Gartner (Stamford, Connecticut) 9. Wibbitz (New York) 10. Pipedrive (New York) 11. Next Caller (New York) 12. AdTheorent (New York) 13. Accenture (New York) 14. Mobilewalla (New York) 15. Rokt (New York)Best places to work in Salt Lake City regionHighest ranked 1. Workfront (Lehi, Utah) 2. Qualtrics (Provo, Utah) 3. Overstock.com (Midvale, Utah) 4. Divvy (Lehi, Utah) 5. Vivint Smart Home (Provo, Utah) 6. Disruptive Advertising, Inc. (Lindon, Utah) 7. BambooHR (Lindon, Utah) 8. Canopy Tax (Lehi, Utah) 9. Skipio(Lehi, Utah) 10. TravelPass Group (Lehi, Utah) 11. Lingotek (Lehi, Utah) 12. Simplus (Salt Lake City) 13. Boostability (Lehi, Utah) 14. Finicity (Murray, Utah) 15. Lift Credit (Provo, Utah)MethodologyComparably’s Best Companies list is derived from sentiment ratings provided by employees in each region who anonymously rated their employers on Comparably.com between March 8, 2018, and March 8, 2019. To qualify, large companies must have a minimum of 50 employee participants and small to mid-size companies must have a minimum of 15 employee participants. Winners were determined based on a series of over 50 structured workplace questions in core culture categories, including compensation, leadership, professional development, work-life balance, perks and benefits. ©2019 USA Today Distributed by Tribune Content Agency, LLC. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Google, Microsoft and Starbucks are some of the best places to work in the US, workers say (2019, March 29) retrieved 17 July 2019 from https://phys.org/news/2019-03-google-microsoft-starbucks-workers.html
Rajasthan: RSS shakha attacked in Bundi, two heldOn July 10, an RSS shakha was organised in a park, where a clash erupted between some people and RSS volunteers over some issue, which is not clear yet, police said. advertisement Asian News International BundiJuly 12, 2019UPDATED: July 12, 2019 17:57 IST Clash erupted between two groups during an ongoing session at an RSS shakha. (Screengrab from ANI video)Two persons were arrested for allegedly attacking a Rashtriya Swayamsevak Sangh (RSS) shakha (camp) here in Bundi district, police said on Friday. On July 10, an RSS shakha was organised in a park, where a clash erupted between some people and RSS volunteers over some issue, which is not clear yet, police said.According to the Sangh, some young boys, who participated in the event, sustained injuries in the incident as they were beaten up by a mob.Soon after receiving information, the police rushed to the spot and tried to pacify the situation. Police arrested two persons after RSS volunteers demanded strict action against the accused.”It is not an old matter. We used to organise our sessions in this park. On Wednesday evening, people from Muslim community opposed the session and started using abusive language for us. When we asked them to move away, they began fighting with us. A few of them also beat up our children,” an RSS volunteer said”We have filed a complaint with police and they assured us that strict action would be taken against the accused. However, they were given bail later and we are not happy with the probe,” he said.Meanwhile, Bundi Superintendent of Police said that they have set up a team who is patrolling the park. He said two persons have been arrested in the case and they are being interrogated by the police.”We are investigating the matter. It was not a serious case, an altercation took place between RSS volunteers and some Muslims. If anyone found guilty, we will surely arrest them,’ he said.Also Read | RSS leader Chandrakant Sharma dies after militant attackAlso Read | RSS’s role in nation-building’ part of Maharashtra varsity syllabusFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Next